Our Recent Publications

Research & Development

  • 2026 Feb 28;14(3):222.
    DOI:
    10.3390/vaccines14030222.

    Plant-Produced Broadly Neutralizing Influenza Monoclonal Antibody CR9114 Exhibits Activity Against Heterologous Avian Influenza Viruses

    Read

    Jaratsittisin J, Aung WW, Rattanapisit K, Suwanchaikasem P, Matphong W, Srisutthisamphan K, Wanasen N, Teeravechyan S, Phoolcharoen W

  • 2026 Feb 17;49:e00951.
    DOI:
    10.1016/j.btre.2026.e00951.

    Development of anti-dengue virus D8 neutralizing monoclonal antibody production in Nicotiana benthamiana

    Read

    Niyompun G, Rattanapisit K, Jaratsittisin J, Suwanchaikasem P, Sootichote R, Sittikul P, Pitaksajjakul P, Ramasoota P, Phoolcharoen W

  • 2025 Dec 30;49:e00944.
    DOI:
    10.1016/j.btre.2025.e00944.
    PMID: 41550789.

    Plant-produced monoclonal antibodies recognize the native circumsporozoite protein on Plasmodium falciparum sporozoites

    Read

    Thiganta K, Rattanapisit K, Suwanchaikasem P, Roobsoong W, Bulaon CJI, Phoolcharoen W

  • 2025 Nov 7;13(4):59.
    DOI:
    10.3390/proteomes13040059.
    PMID: 41283649.

    Proteomic Analysis of Plant-Derived hIGF-1-Fc Reveals Proteome Abundance Changes Associated with Wound Healing and Cell Proliferation

    Read

    Kittirotruji K, Ngaokrajang U, Buranasudja V, Sujarittham I, Nwe SY, Suwanchaikasem P, Rattanapisit K, Bulaon CJI, Phoolcharoen W

  • 2025 Sep 29;48:e00927.
    DOI:
    10.1016/j.btre.2025.e00927.
    PMID: 41104009.

    Glycoengineering of plant-produced Pembrolizumab enhances FcRn binding and extends serum half-life in mice

    Read

    Bulaon CJI, Jaratsittisin J, Rattanapisit K, Suwanchaikasem P, Guo S, Boonha K, Pitaksajjakul P, Simsom N, Limprasutr V, Phoolcharoen W

  • 2025;1:6.
    DOI:
    10.1038/s44383-025-00005-5.

    Sustainable production of functional human serum albumin in Nicotiana benthamiana: a green biomanufacturing approach

    Read

    Sujarittham I, Ngaokrajang U, Suwanchaikasem P, Rattanapisit K, Jirananon K, Bulaon CJI, Phoolcharoen W

  • 2025;15:25635.
    DOI:
    10.1038/s41598-025-11541-6.

    LC-MS determination of Nicotiana benthamiana host plant proteins in the drug products of recombinant plant-produced pembrolizumab

    Read

    Daduang R, Suwanchaikasem P, Rattanapisit K, Vitayathikornnasak S, Bulaon CJI, Srisangsung T, Bulaon CJI, Phoolchareon W

  • 2025;46:e00889.
    DOI:
    10.1016/j.btre.2025.e00889.
    PMID: 40235517.

    Optimized expression of human interleukin-15 in Nicotiana benthamiana and in vitro assessment of its activity on human keratinocytes

    Read

    Charnsatabut C, Suwanchaikasem P, Rattanapisit K, Iksen I, Pongrakhananon V, Bulaon CJI, Phoolcharoen W

  • 2025;20(1):e0316790.
    DOI:
    10.1371/journal.pone.0316790.
    PMID: 39808627.

    Plant-derived Pembrolizumab in conjugation with IL-15Rα-IL-15 complex shows effective anti-tumor activity

    Read

    Rattanapisit K, Suwanchaikasem P, Bulaon CJI, Guo S, Phoolcharoen W

  • 2025;159:06004.
    DOI:
    10.1051/bioconf/202515906004.

    Plant-Based Expression and Structural Characterization of M2e-HBc Virus-Like Particle in Nicotiana benthamiana

    Read

    Bo MKK, Phoolcharoen W

  • 2025;159:06005.
    DOI:
    10.1051/bioconf/202515906005.

    Plant-Based Production and Purification of Functional Anti-CD3 Antibody Using Agrobacterium-Mediated Expression

    Read

    Liewtrakool P, Phoolcharoen W

  • 2024;20(1):2329446.
    DOI:
    10.1080/21645515.2024.2329446.
    PMID: 38525945.

    Production of monoclonal antibodies against botulinum neurotoxin in Nicotiana benthamiana

    Read

    Sangprasat K, Bulaon CJI, Rattanapisit K, Srisangsung T, Jirarojwattana P, Wongwatanasin A, Phoolcharoen W

  • 2024;20(1):2327142.
    DOI:
    10.1080/21645515.2024.2327142.
    PMID: 38508690.

    Neutralizing activity of anti-respiratory syncytial virus monoclonal antibody produced in Nicotiana benthamiana

    Read

    Pisuttinusart N, Rattanapisit K, Srisaowakarn C, Thitithanyanont A, Strasser R, Shanmugaraj B, Phoolcharoen W

  • 2024;43:e00847.
    DOI:
    10.1016/j.btre.2024.e00847.

    The impact of N-glycans on the immune response of plant-produced SARS-CoV-2 RBD-Fc proteins

    Read

    Srisangsung T, Phetphoung T, Manopwisedjaroen S, Rattanapisit K, Bulaon CJI, Thitithanyanont A, Limprasutr V, Strasser R, Phoolcharoen W

  • 2024;42:e00844.
    DOI:
    10.1016/j.btre.2024.e00844.

    Nicotiana benthamiana as a potential source for producing anti-dengue virus D54 neutralizing therapeutic antibody

    Read

    Krittanai S, Rattanapisit K, Bulaon CJI, Pitaksajjakul P, Keadsanti S, Ramasoota P, Strasser R, Phoolcharoen W

  • 2024 Apr 16;42:e00841.
    DOI:
    10.1016/j.btre.2024.e00841.

    Characterization of plant produced VHH antibodies against cobra venom toxins for antivenom therapy

    Read

    Vitayathikornnasak S, Rattanapisit K, Malla A, Suwanchaikasem P, Strasser R, Khorattanakulchai N, Pothisamutyothin K, Arunmanee W, Phoolcharoen W

  • 2024 Apr;90(4):305-315.
    DOI:
    10.1055/a-2240-7534.

    Development of Plant-Derived Bispecific Monoclonal Antibody Targeting PD-L1 and CTLA-4 against Mouse Colorectal Cancer

    Read

    Bulaon CJI, Khorattanakulchai N, Rattanapisit K, Sun H, Pisuttinusart N, Phoolcharoen W.

  • 2023 Dec 23;41:e00826.
    DOI:
    10.1016/j.btre.2023.e00826.
    eCollection 2024 Mar.

    Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice

    Read

    Pisuttinusart N, Shanmugaraj B, Srisaowakarn C, Ketloy C, Prompetchara E, Thitithanyanont A, Phoolcharoen W., Biotechnol Rep (Amst)

  • 2023 Aug;28(4):278-291.
    DOI:
    10.1016/j.slast.2023.03.002.
    Epub 2023 Mar 24.

    Plant molecular farming-derived epidermal growth factor revolutionizes hydrogels for improving glandular epithelial organoid biofabrication

    Read

    Phan TV, Oo Y, Rodboon T, Nguyen TT, Sariya L, Chaisuparat R, Phoolcharoen W, Yodmuang S, Ferreira JN., SLAS Technol

  • 2023 Aug;89(10):1010-1020.
    DOI:
    10.1055/a-2076-2034.
    Epub 2023 Apr 18.

    Molecular Farming Strategy for the Rapid Production of Protein-Based Reagents for Use in Infectious Disease Diagnostics

    Read

    Shanmugaraj B, Jirarojwattana P, Phoolcharoen W., Planta Med

  • 2023 Aug 29;13(1):14146.
    DOI:
    10.1038/s41598-023-41510-w.

    In vitro and in vivo studies of plant-produced Atezolizumab as a potential immunotherapeutic antibody

    Read

    Rattanapisit K, Bulaon CJI, Strasser R, Sun H, Phoolcharoen W., Sci Rep

  • 2023 Aug 29;14:1149455.
    DOI:
    10.3389/fpls.2023.1149455.
    eCollection 2023.
    PMID: 37711295.

    Antitumor effect of plant-produced anti-CTLA-4 monoclonal antibody in a murine model of colon cancer

    Read

    Bulaon CJI, Khorattanakulchai N, Rattanapisit K, Sun H, Pisuttinusart N, Strasser R, Tanaka S, Soon-Shiong P, Phoolcharoen W., Front Plant Sci

  • 2023 Aug 17;11(8):1377.
    DOI:
    10.3390/vaccines11081377.
    PMID: 37644106.

    Efficiency Comparative Approach of Plant-Produced Monoclonal Antibodies against Rabies Virus Infection

    Read

    Lumlertdacha B, Mahong B, Rattanapisit K, Bulaon CJI, Hemachudha T, Phoolcharoen W., Vaccines (Basel)

  • 2023 Jun;38:e00796.
    DOI:
    10.1016/j.btre.2023.e00796.
    Epub 2023 Apr 6.

    Development of SARS-CoV-2 neutralizing antibody detection assay by using recombinant plant-produced proteins

    Read

    Jirarojwattana P, Shanmugaraj B, Rattanapisit K, Phoolcharoen W., Biotechnol Rep (Amst)

  • 2023 Apr 24;41(17):2781-2792.
    DOI:
    10.1016/j.vaccine.2023.03.027.
    Epub 2023 Mar 21.

    Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant

    Read

    Phoolcharoen W, Shanmugaraj B, Khorattanakulchai N, Sunyakumthorn P, Pichyangkul S, Taepavarapruk P, Praserthsee W, Malaivijitnond S, Manopwisedjaroen S, Thitithanyanont A, Srisutthisamphan K, Jongkaewwattana A, Tomai M, Fox CB, Taychakhoonavudh S., Vaccine

  • 2023 Mar 28;38:e00794.
    DOI:
    10.1016/j.btre.2023.e00794.
    eCollection 2023 Jun.

    Therapeutic efficacy of plant-produced Nivolumab in transgenic C57BL/6-hPD-1 mouse implanted with MC38 colon cancer

    Read

    Bulaon CJI, Sun H, Malla A, Phoolcharoen W., Biotechnol Rep (Amst)

  • Social and Administrative Pharmacy

  • 2023 Nov;50(11):1427-1432.
    DOI:
    10.1111/1346-8138.16903.
    Epub 2023 Jul 20.
    PMID: 37475211.

    Randomized controlled trial and cost-effectiveness analysis: Comparing chlorhexidine scrub, ZnO-nanoparticle socks, and their combination in pitted keratolysis treatment

    Read

    Leeyaphan C, Kulthanachairojana N, Taychakhoonavudh S, Chanyachailert P, Kobkurkul P, Buranaporn P, Yenyuwadee S, Matthapan L, Prasong W, Panyawong C, Bunyaratavej S.J Dermatol

  • 2023 Jul 27;13(1):12154.
    DOI:
    10.1038/s41598-023-39264-6.
    PMID: 37500677.

    Using a discrete choice experiment to elicit patients’ preferences and willingness-to-pay for knee osteoarthritis treatments in Thailand

    Read

    Luksameesate P, Tanavalee A, Ngorsuraches S, Taychakhoonavudh S.Sci Rep

  • 2023 Jul 19;18(7):e0288723.
    DOI:
    10.1371/journal.pone.0288723.
    eCollection 2023.
    PMID: 37467278.

    Antivenom preclinical efficacy testing against Asian snakes and their availability in Asia: A systematic review

    Read

    Soopairin S, Patikorn C, Taychakhoonavudh S.PLoS One

  • 2023 May 24;23(1):533.
    DOI:
    10.1186/s12913-023-09530-4.
    PMID: 37226134.

    Impact of prescription length supply policy on patient medication adherence in Thailand

    Read

    Jarujumrus I, Taychakhoonavudh S.BMC Health Serv Res

  • 2023 Apr 24;41(17):2781-2792.
    DOI:
    10.1016/j.vaccine.2023.03.027.
    Epub 2023 Mar 21.
    PMID: 36963999.

    Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant

    Read

    Phoolcharoen W, Shanmugaraj B, Khorattanakulchai N, Sunyakumthorn P, Pichyangkul S, Taepavarapruk P, Praserthsee W, Malaivijitnond S, Manopwisedjaroen S, Thitithanyanont A, Srisutthisamphan K, Jongkaewwattana A, Tomai M, Fox CB, Taychakhoonavudh S.Vaccine

  • 2022 Nov 16;16(11):e0010915.
    DOI:
    10.1371/journal.pntd.0010915.
    eCollection 2022 Nov.
    PMID: 36383562.

    Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis

    Read

    Patikorn C, Ismail AK, Zainal Abidin SA, Othman I, Chaiyakunapruk N, Taychakhoonavudh S.PLoS Negl Trop Dis

  • 2022 Sep 26;13:926431.
    DOI:
    10.3389/fphar.2022.926431.
    eCollection 2022.
    PMID: 36225578.

    An economic evaluation of knee osteoarthritis treatments in Thailand

    Read

    Luksameesate P, Tanavalee A, Taychakhoonavudh S.Front Pharmacol

  • Publications