Surface Plasmon Resonance (SPR)
Powerful services for your biomolecular interaction research, SPR monitors binding events in real time by detecting shifts in the refractive index at a sensor's surface.
SPR Capabilities & Applications
Complete Kinetic &
Affinity Profiling
Precisely determine binding kinetics
(ka, kd) and affinity (KD) to quantitatively characterize biomolecular interactions.
(ka, kd) and affinity (KD) to quantitatively characterize biomolecular interactions.
Antibody Half-life
Ranking Panel
Utilize FcRn binding panel to analyze pH-dependent interactions, enabling
to forecast the in vivo half-life of your antibody candidates.
to forecast the in vivo half-life of your antibody candidates.
Custom Assay
Development
Design novel, project-specific SPR methodologies to address unique research challenges or non-standard interactions.
SPR Service Packages
Package A: Lead Selection
High-throughput screening to rapidly rank antibody candidates by affinity (KD).
☑ Rapid kinetic screening
☑ Ranking report based on ka, kd, and affinity constants (KD)
☑ Selection of the best binders for further characterization
Package B: Half-life Predictor
Predict in vivo half-life early via pH-dependent FcRn binding analysis.
☑ Physiological pH (7.4) for circulation check
☑ Endosomal pH (6.0) for recycling check
Package C: Safety & Effector Function
FcγR panel profiling for Safety and Effector Function prediction.
☑ Full kinetic analysis against key FcγR receptors (e.g., FcγRI, FcγRIIa, FcγRIIIa, FcγRIIb)
Package D: Customized
Tailor-made experimental design for complex research challenges.
☑ Deep consultation & bespoke method development
Deliverables
● Raw Sensorgrams:
Access the original, real-time binding curves, allowing you to see the association and dissociation events as they happened.
● Final Kinetic and Affinity Data:
A clear, concise report of all processed ka, kd, and KD values for easy comparison.
● Data Quality and Fitting Models:
We provide visual graphs of all data fits, validated by goodness-of-fit metrics, so you can be confident in the results.
● Insights Report:
A comprehensive summary report that translates the data into key findings.